2 edition of Liquid chromatography-mass spectrometry in forensic and clinical toxicology. found in the catalog.
Liquid chromatography-mass spectrometry in forensic and clinical toxicology.
Hans H. Maurer
Written in English
Taken from Journal of chromatography B, vol.713, 1998, pp.3-25.
|Series||Journal of chromatography B -- v713|
This paper reviews multi-analyte single-stage and tandem liquid chromatography–mass spectrometry (LC-MS) procedures using different mass analyzers (quadrupole, ion trap, time-of-flight) for screening, identification, and/or quantification of drugs, poisons, and/or their metabolites in blood, plasma, serum, or urine published after Basic information about the biosample assayed, work . Liquid chromatography (LC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) has become increasingly important in clinical and forensic toxicology as well as doping control and is now a robust and reliable technique for routine analysis in these ﬁelds. In recent years, methods for LC–MS(/MS)-.
Role of liquid chromatography–high-resolution mass spectrometry (LC-HR/MS) in clinical toxicology Alan Hb Wu Department of Laboratory Medicine, University of California, San Francisco, CA; Clinical Chemistry and Toxicology Laboratories, San Francisco General Hospital, San Francisco, CA Correspondence [email protected] by: In the last decade, liquid chromatography coupled to (tandem) mass spectrometry (LC–MS(−MS)) has become a versatile technique with many routine applications in clinical and forensic toxicology. However, it is well-known that ionization in LC–MS(−MS) is prone to so-called matrix effects, i.e., alteration in response due to the presence of co-eluting compounds that may increase (ion.
Recently, some clinical toxicology laboratories have adopted liquid chromatography-mass spectrometry (LC-MS) as a complementary method to GC-MS and LC-UV for CDS [3–6]. Unlike GC-MS, LC-MS(/MS) using electrospray ionization (ESI) is capable of detecting non-volatile, polar and thermally labile drugs and provides a means of detecting a broad. Detect a trace when time is precious. Get confident quantitation without sacrificing uptime – for fast, accurate forensic examination. From identifying and quantifying steroids, to the quantitation of illicit drugs, cutting edge forensic toxicology demands high sensitivity, precision and reliability.
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A relatively limited number of papers concerning applications of liquid chromatography–mass spectrometry (LC–MS) to forensic or clinical toxicology, or analytical methods directly applicable to these topics have been published so far, but their number have greatly increased in the past two years, probably due to technical improvements and to a decrease in the price of such instruments.
Liquid chromatography-mass spectrometry in forensic toxicology Article Literature Review (PDF Available) in Mass Spectrometry Reviews 19(4) July with 1, Reads.
Liquid chromatography mass spectrometry. The focus of this chapter is the use of LC-MS for toxicology testing in the clinical laboratory. The use of LC-MS has become increasingly more prominent in clinical toxicology laboratories for drug confirmation testing Cited by: 3.
Introduction. In forensic and clinical toxicology analytical methods must provide high reliability and accuracy.
The combinations of mass spectrometry with suitable chromatographic procedures are the methods of choice, because they are very sensitive, precise, specific, universal and by: Download Citation | Toxicology: Liquid chromatography mass spectrometry | LC-MS is a powerful tool for toxicology applications in the clinical laboratory.
The primary use of an LC-MS in a. A relatively limited number of papers concerning applications of liquid chromatography–mass spectrometry (LC–MS) to forensic or clinical toxicology, or analytical methods directly applicable to these topics have been published so far, but their number have greatly increased in the past two years, probably due to technical improvements and to a decrease in the price of such by: Liquid chromatography (LC) coupled to mass spectrometry (MS) or tandem mass spectrometry (MS/MS) has become increasingly important in clinical and forensic toxicology as well as doping control and is now a robust and reliable technique for routine analysis in these by: Liquid chromatography—mass spectrometry has evolved from a topic of mainly research interest into a routinely usable tool in various application fields.
With the advent of new ionization approaches, especially atmospheric pressure, the technique has established itself firmly in many areas of research.
Applications of liquid chromatography in the quality control of traditional Chinese medicines: An overview Analysis of neurotransmitters and their metabolites by liquid chromatography Principles, current applications, and future perspectives of liquid chromatography mass spectrometry in clinical.
They cover mainly gas chromatography-mass spectrometry and liquid Forensic toxicology and clinical toxicology cut across these areas. cases were of clinical toxicology. Out of LIQUID CHROMATOGRAPHY–MASS SPECTROMETRY IN FORENSIC TOXICOLOGY Jan F.
Van Bocxlaer,1 Karine M. Clauwaert,1 Willy E. Lambert,1 Dieter L. Deforce,2 Elfriede G. Van den Eeckhout,2 and Andre´ P. vi Liquid Chromatography–Mass Spectrometry Quantitation Using High Performance Liquid Chromatography 23 The Need for High Performance Liquid Chromatography– Mass Spectrometry 30 References 31 3 Mass Spectrometry 33 Introduction 33 Ionization Methods 36 Electron Ionization 36 Chemical Ionization 36 Fast-Atom.
Forensic Toxicology, the latest release in the Advanced Forensic Science Series that grew out of recommendations from the NAS Report, Strengthening Forensic Science: A Path Forward will serve as a graduate level text for those studying and teaching forensic toxicology.
It is also an excellent reference for the forensic practitioner’s library or for use in their casework. Modern technology using state-of-the-art equipment can now identify almost any toxin relevant to a legal issue. Techniques include gas chromatography, mass spectrometry, high-pressure liquid chromatography, and the combination of these methods.
Forensic Toxicology: Medico-legal Case Studies demonstrates how the science of forensic toxicology acts a.
Professor R.L. Bertholf, Associate Professor and Director of Clinical Chemistry and Toxicology, Department of Pathology, University of Florida Health Science Center, Jacksonville, FL, USA.
Dr R.E. Winecker, Chief Toxicologist, North Carolina Office of the Chief Medical Examiner. Maurer HH () Liquid chromatography-mass spectrometry in forensic and clinical toxicology. J Chromatogr B Biomed Sci Appl 3–25 PubMed CrossRef Google Scholar Liquid chromatography–mass spectrometry in forensic and clinical toxicology1 Hans H.
Maurer Institute of Pharmacology and Toxicology,Department of Toxicology,University of Saarland,DHomburg (Saar),Germany Abstract This paper reviews liquid chromatographic–mass spectrometric (LC–MS) procedures for the identiﬁcation and/or.
LC-MS webinar series expands application knowledge for research in omics, pharma/biopharma, clinical, forensic toxicology, food & beverage testing and environmental testing.
In the last few years, the increased use of liquid chromatography-mass spectrometry (LC-MS) in various analytical fields, including forensic and clinical toxicology, has been spectacular.
This class is HANDS-ON (click on the above to see) In this class you will not only be instructed in the classroom theory that underlies chromatography (both liquid and gas chromatography) in general and the specific theories that allow for headspace analysis and how Flame Ionization Detector, UV-DAD and Mass Spectrometry (EI and EC based) works, and get to see the instruments, but you will do.
Current role of liquid chromatography-mass spectrometry in clinical and forensic toxicology. Maurer HH(1). Author information: (1)Department of Experimental and Clinical Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, Saarland University, Homburg (Saar), Germany.
@d by: Progress of Liquid Chromatography–Mass Spectrometry in Clinical and Forensic Toxicology Pierre Marquet Department of Pharmacology and Toxicology, University Hospital, Limoges, France Summary: The use of liquid chromatography–mass spectrometry (LC-MS) has re-cently exploded in various analytic fields, including toxicology and therapeutic drug.Liquid chromatography–mass spectrometry (LC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS).
Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically.